Tretinoin Microsphere Gel is a topical medication used to treat acne and other skin conditions. It contains a form of vitamin A called tretinoin, which works by increasing cell turnover and preventing the clogging of pores. The “microsphere” component refers to the tiny beads within the gel that help to slowly release the medication over time. This can reduce irritation and make it a more effective treatment option for those with sensitive skin. Tretinoin Microsphere Gel is available only by prescription and should be used as directed by a healthcare professional.